vky wrote:@BGL, just wondering out loud here what, are the odds that a person who suffered an autoimmune disease say myasthenia gravis and fully recovered, develop some form of immunity against hiv. it doesn't have to be the quoted disease but any autoimmune disease where 100% remission was reported
@vky
I like this kind of questions......
The population of Caucasians that are resistant to R5 tropic HIV survived a plaque which wiped a huge population in that part of the world. The consequence of the survivors was deletion of the gene that is responsible for the expression of the receptor that HIV uses to enter the cell.
SO IT IS POSSIBLE but not absolute.
The basics of MG:
Myasthenia gravis (MG) is an autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatigability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction.
Open questions:What is an immune disorder? see the description of MG
Is HIV an autoimmune disorder? NO
What is the target cells for HIV? Immune cells that express CD4 receptor and a coreceptor (CCR5 or CXCR4) or both.
What is the target cell for anti-MG antibodies? Nerve cells expressing acetylcholine receptors.
My own personal views restricted to MG and HIVMG and HIV do not share the same target cells nor do they enter the cells using similar receptor
MG is an autoimmune (self attacking self) while HIV causes Immune deficiency (lack of immunity).
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